Article
Survival analysis of life span quantitative trait loci in Drosophila melanogaster.
Genetics - 1 Jun 2005
Nuzhdin Sergey V, Khazaeli Aziz A, Curtsinger James W
Abstract excerpt
We used quantitative trait loci (QTL) mapping to evaluate the age specificity of naturally segregating alleles affecting life span. Estimates of age-specific mortality rates were obtained from observing 51,778 mated males and females from a panel of 144 recombinant inbred lines (RILs). Twenty-five QTL were found, having 80 significant effects on life span and weekly mortality rates. Generation of RILs from...
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