Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide analysis in Drosophila reveals age-specific effects of SNPs on fitness traits.

Nature communications - 8 Jul 2014

Durham Mary F, Magwire Michael M, Stone Eric A, Leips Jeff

Abstract excerpt

Most organisms exhibit senescence; a decline in physiological function with age. In nature, rates of senescence vary extensively among individuals and this variation has a significant genetic component; however, we know little about the genes underlying senescence. Here we show the first evidence that individual alleles influence fecundity in an age-specific manner and so the genetic basis of natural variation in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Drosophila melanogaster
Share to Fertility

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Ontology

Share to Genetic Fitness

Share to Genome-Wide Association Study

Share to Mutation

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 25000897
DOI: 10.1038/ncomms5338

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide analysis in Drosophila reveals age-specific effects of SNPs on fitness traits.PMID 25000897Read ↗

Quantitative trait loci with age-specific effects on fecundity in Drosophila melanogaster.Semantic proximity Read ↗

Sex-specific quantitative trait loci affecting longevity in Drosophila melanogaster.Semantic proximity Read ↗

Age-specific effects of deletions: implications for aging theories.Semantic proximity Read ↗

Quantitative genetic tests of recent senescence theory: age-specific mortality and male fertility in Drosophila melanogaster.Semantic proximity Read ↗

The Genomic Basis of Postponed Senescence in Drosophila melanogaster.Semantic proximity Read ↗

The evolution of aging and lifespan.Semantic proximity Read ↗

Deleterious mutations show increasing negative effects with age in Drosophila melanogaster.Semantic proximity Read ↗

Genetics of aging.Semantic proximity Read ↗

Reproductive activity triggers accelerated male mortality and decreases lifespan: genetic and gene expression determinants in Drosophila.Semantic proximity Read ↗

Evidence for the role of selection for reproductively advantageous alleles in human aging.Semantic proximity Read ↗

Genetic insights into the biological mechanisms governing human ovarian ageingSemantic proximity Read ↗

Age-specific effects of novel mutations in Drosophila melanogaster II. Fecundity and male mating ability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.