Mapping genetic polymorphisms affecting natural variation in Drosophila longevity.

Abstract excerpt

Analyses of mutations affecting life span in model organisms have revealed a number of genes that regulate longevity in evolutionarily conserved signaling pathways. These studies suggest that genes involved in insulin-like signaling pathways, metabolism, stress response, and prevention of oxidative damage influence life span. However, we do not know whether functional polymorphisms at these candidate genes affect...

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