Article
Prevalence of factor V Leiden mutation in various populations.
Genetic epidemiology - 1 Jan 1997
Herrmann F H, Koesling M, Schrŏder W, Altman R, Jiménez Bonilla R, Lopaciuk S, Perez-Requejo J L, Singh J R
Abstract excerpt
Resistance to activated protein C (APC) is the most common inherited risk factor for venous thrombosis. Most cases of APC resistance are caused by the point mutation nt 1691 G-A in factor V gene, referred to as factor V Leiden mutation. As initially shown in a Dutch population, this mutation has a carrier rate of 2.9%, the most frequent genetic disposition for thrombophilia and deep venous thrombosis. By...
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