Activated protein C resistance and factor V Leiden: a review.

Abstract excerpt

CONTEXT: Factor V Leiden (FVL) is the most common heritable cause of venous thrombosis. It is caused by a single nucleotide substitution resulting in an R506Q missense mutation, resulting in factor V resistance to activated protein C (APC) inactivation. Carriers of FVL have an increased susceptibility to venous thrombosis, which is further increased in the presence of other genetic or environmental risk factors....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Activated Protein C Resistance
• Share to Disease Models, Animal
• Share to Factor V