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Article

Prevalence of the factor V-Leiden mutation in four distinct American ethnic populations.

American journal of medical genetics - 19 Dec 1997

Gregg J P, Yamane A J, Grody W W

Abstract excerpt

Resistance to activated protein C (APC) is the most common risk factor for venous thromboembolism, a major cause of morbidity and mortality with an incidence of about 1/1,000 per year. The Arg 506 to Gln mutation in exon 10 of the coagulation factor V gene (factor V-Leiden) has been found to be responsible for over 90% of the APC resistance cases and is an autosomal dominant trait. Initial studies have suggested...

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Source

Identifiers

PMID: 9415695
DOI: 10.1002/(sici)1096-8628(19971219)73:3<334::aid-ajmg20>3.0.co;2-j

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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