Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Plasminogen activator inhibitor-1 is a major determinant of arterial thrombolysis resistance.

Circulation - 15 Jun 1999

Zhu Y, Carmeliet P, Fay W P

Abstract excerpt

BACKGROUND: Platelet-rich thrombi are resistant to lysis by tissue plasminogen activator (tPA). Plasminogen activator inhibitor-1 (PAI-1), a rapid inhibitor of tPA, may contribute to arterial thrombolysis resistance. However, few data are available regarding the effect of PAI-1 on arterial thromb...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carotid Arteries
Share to Carotid Stenosis
Share to Chlorides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ferric Compounds

Share to Plasminogen

Share to Plasminogen Activator Inhibitor 1

Share to Thrombosis

Share to Tissue Plasminogen Activator

Source

Identifiers

PMID: 10368124
DOI: 10.1161/01.cir.99.23.3050

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10368124-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Plasminogen activator inhibitor-1 is a major determinant of arterial thrombolysis resistance.PMID 10368124Read ↗

Plasminogen activator inhibitor-1 and its cofactor vitronectin stabilize arterial thrombi after vascular injury in mice.Semantic proximity Read ↗

Effects of plasminogen activator inhibitor-1 on ischemic brain injury in permanent and thrombotic middle cerebral artery occlusion models in mice.Semantic proximity Read ↗

Remodeling of the vessel wall after copper-induced injury is highly attenuated in mice with a total deficiency of plasminogen activator inhibitor-1.Semantic proximity Read ↗

COX-1(+/-)COX-2(-/-) genotype in mice is associated with shortened time to carotid artery occlusion through increased PAI-1.Semantic proximity Read ↗

Endogenous plasminogen activators mediate progressive intracerebral hemorrhage after traumatic brain injury in mice.Semantic proximity Read ↗

Platelets inhibit fibrinolysis in vitro by both plasminogen activator inhibitor-1-dependent and -independent mechanisms.Semantic proximity Read ↗

Effective lysis of model thrombi by a t-PA mutant (A473S) that is resistant to alpha2-antiplasmin.Semantic proximity Read ↗

Plasminogen activator inhibitor type 1 enhances neointima formation after oxidative vascular injury in atherosclerosis-prone mice.Semantic proximity Read ↗

Inhibiting monocyte migration reduces arterial thrombosis and facilitates thrombolysisSemantic proximity Read ↗

Deficiency of tissue factor pathway inhibitor promotes atherosclerosis and thrombosis in mice.Semantic proximity Read ↗

Influence of plasminogen deficiency on the contribution of polymorphonuclear leucocytes to fibrin/ogenolysis: studies in plasminogen knock-out mice.Semantic proximity Read ↗

Humanizing thrombi in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.