Article
Chromosomal mapping and mutational analysis of the coding region of the glycogen synthase kinase-3alpha and beta isoforms in patients with NIDDM.
Diabetologia - 1 Aug 1997
Hansen L, Arden K C, Rasmussen S B, Viars C S, Vestergaard H, Hansen T, Møller A M, Woodgett J R, Pedersen O
Abstract excerpt
Activation of glycogen synthesis in skeletal muscle in response to insulin results from the combined inactivation of glycogen synthase kinase-3 (GSK-3) and activation of the protein phosphatase-1, changing the ratio between the inactive phosphorylated state of the glycogen synthase to the active dephosphorylated state. In a search for genetic defects responsible for the decreased insulin stimulated glycogen...
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