Article
A widespread amino acid polymorphism at codon 905 of the glycogen-associated regulatory subunit of protein phosphatase-1 is associated with insulin resistance and hypersecretion of insulin.
Human molecular genetics - 1 Aug 1995
Hansen L, Hansen T, Vestergaard H, Bjørbaek C, Echwald S M, Clausen J O, Chen Y H, Chen M X, Cohen P T, Pedersen O
Abstract excerpt
The regulatory G-subunit of the glycogen-associated form of protein phosphatase 1 (PP1) plays a crucial part in muscle tissue glycogen synthesis and breakdown. As impaired insulin stimulated glycogen synthesis in peripheral tissues is considered to be a pathogenic factor in subsets of non-insulin-dependent diabetes mellitus (NIDDM) and obesity, the G-subunit of PP1 should be viewed as a candidate gene for...
Topics
- Base Sequence
- Case-Control Studies
- DNA
- DNA Primers
- Diabetes Mellitus, Type 2
- Female
- Gene Frequency
- Genetic Variation
- Glucose
- Glycogen