Article
Molecular and linkage analysis of type-1 protein phosphatase catalytic beta-subunit gene: lack of evidence for its major role in insulin resistance in Pima Indians.
Diabetologia - 1 Apr 1995
Prochazka M, Mochizuki H, Baier L J, Cohen P T, Bogardus C
Abstract excerpt
Insulin resistance is believed to be a prediabetic condition that results from reduced rates of insulin-mediated glycogen synthesis in skeletal muscle. A decrease in activities of skeletal muscle glycogen synthase and of its regulatory enzyme type-1 protein phosphatase (PP 1) have been previously...
Topics
- Alternative Splicing
- Base Sequence
- Child, Preschool
- DNA Primers
- Exons
- Genetic Linkage
- Genetic Markers
- Genetic Variation
- Humans
- Indians, North American
- Insulin Resistance
- Introns
- Macromolecular Substances
- Molecular Sequence Data
- Phosphoprotein Phosphatases
- Polymerase Chain Reaction
- Polymorphism, Genetic
- White People