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Article

Association between polymorphism of the glycogen synthase gene and non-insulin-dependent diabetes mellitus.

The New England journal of medicine - 7 Jan 1993

Groop L C, Kankuri M, Schalin-Jäntti C, Ekstrand A, Nikula-Ijäs P, Widén E, Kuismanen E, Eriksson J, Franssila-Kallunki A, Saloranta C

Abstract excerpt

BACKGROUND: The storage of glucose as glycogen in skeletal muscle is frequently impaired in patients with non-insulin-dependent diabetes mellitus (NIDDM) and their nondiabetic relatives. Despite an intensive search for candidate genes associated with NIDDM, no data have been available on the gene coding for the key enzyme of this pathway, glycogen synthase. METHODS AND RESULTS: Using a human complementary DNA...

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PMID: 8416266
DOI: 10.1056/NEJM199301073280102

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