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Article

Revertant fibres: a possible genetic therapy for Duchenne muscular dystrophy?

Neuromuscular disorders : NMD - 1 Jul 1997

Wilton S D, Dye D E, Blechynden L M, Laing N G

Abstract excerpt

The mdx mouse, an animal model used to study Duchenne muscular dystrophy (DMD), has a nonsense mutation in exon 23 of the dystrophin gene which should result in a truncated protein that cannot be correctly localized at the sarcolemma of the muscle fibres. Immunohistochemical staining with anti-dystrophin antibodies had shown that while most of the muscle tissue was dystrophin-negative, a small percentage of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9267847
DOI: 10.1016/s0960-8966(97)00058-8

Genes

DMD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Revertant fibres: a possible genetic therapy for Duchenne muscular dystrophy?PMID 9267847Read ↗

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Specific removal of the nonsense mutation from the mdx dystrophin mRNA using antisense oligonucleotides.Semantic proximity Read ↗

The frequency of revertants in mdx mouse genetic models for Duchenne muscular dystrophy.Semantic proximity Read ↗

Somatic reversion/suppression in Duchenne muscular dystrophy (DMD): evidence supporting a frame-restoring mechanism in rare dystrophin-positive fibers.Semantic proximity Read ↗

Antisense-induced exon skipping and synthesis of dystrophin in the mdx mouseSemantic proximity Read ↗

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