Article
Dystrophin-positive fibers in Duchenne dystrophy: origin and correlation to clinical course.
Muscle & nerve - 1 Oct 1995
Fanin M, Danieli G A, Cadaldini M, Miorin M, Vitiello L, Angelini C
Abstract excerpt
In 132 DMD muscle biopsies we investigated the presence of dystrophin-positive fibers and the relationship of dystrophin immunohistochemical pattern to the clinical severity of the disease. Reverted fibers were detected in 37% of patients; their prevalence increased significantly in each biopsy with age of patients. We suggest that reversion occurs in satellite cells, when muscle differentiation is completed. The...
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