Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of dystrophin deficient rats: a new model for Duchenne muscular dystrophy.

PloS one - 1 Jan 2014

Larcher Thibaut, Lafoux Aude, Tesson Laurent, Remy Séverine, Thepenier Virginie, François Virginie, Le Guiner Caroline, Goubin Helicia, Dutilleul Maéva, Guigand Lydie, Toumaniantz Gilles, De Cian Anne, Boix Charlotte, Renaud Jean-Baptiste, Cherel Yan, Giovannangeli Carine, Concordet Jean-Paul, Anegon Ignacio, Huchet Corinne

Abstract excerpt

A few animal models of Duchenne muscular dystrophy (DMD) are available, large ones such as pigs or dogs being expensive and difficult to handle. Mdx (X-linked muscular dystrophy) mice only partially mimic the human disease, with limited chronic muscular lesions and muscle weakness. Their small size also imposes limitations on analyses. A rat model could represent a useful alternative since rats are small animals...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Creatine Kinase
Share to Dystrophin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibrosis

Share to Gene Targeting

Share to Muscle Weakness

Share to Muscular Dystrophy, Animal

Share to Muscular Dystrophy, Duchenne

Share to Ventricular Remodeling

Source

Open in PubMed Open full text

Identifiers

PMID: 25310701
DOI: 10.1371/journal.pone.0110371
PMCID: PMC4195719

Genes

DMD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of dystrophin deficient rats: a new model for Duchenne muscular dystrophy.PMID 25310701Read ↗

Functional and structural pathologies in skeletal muscle of a rat model of Duchenne muscular dystrophySemantic proximity Read ↗

A novel mouse model of Duchenne muscular dystrophy carrying a multi-exonic Dmd deletion exhibits progressive muscular dystrophy and early-onset cardiomyopathySemantic proximity Read ↗

A new dystrophin-deficient rat model mirroring exon skipping in patients with DMD exon 45 deletions.Semantic proximity Read ↗

Generation of muscular dystrophy model rats with a CRISPR/Cas system.Semantic proximity Read ↗

A NEW DYSTROPHIN DEFICIENT RAT MODEL MIRRORING EXON SKIPPING IN PATIENTS WITH DMD EXON 45 DELETIONSSemantic proximity Read ↗

Age-Dependent Echocardiographic and Pathologic Findings in a Rat Model with Duchenne Muscular Dystrophy Generated by CRISPR/Cas9 Genome EditingSemantic proximity Read ↗

Current Translational Research and Murine Models For Duchenne Muscular DystrophySemantic proximity Read ↗

Duchenne muscular dystrophy trajectory in R-DMDdel52 preclinical rat model identifies COMP as biomarker of fibrosisSemantic proximity Read ↗

Four new Duchenne muscular dystrophy mouse models with clinically relevant exon deletions in the human <i>DMD</i> geneSemantic proximity Read ↗

Dystrophin-deficient pigs provide new insights into the hierarchy of physiological derangements of dystrophic muscle.Semantic proximity Read ↗

Animal models of muscular dystrophy – what can they teach us?Semantic proximity Read ↗

A scalable, clinically severe pig model for Duchenne muscular dystrophySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.