Article
The frequency of revertants in mdx mouse genetic models for Duchenne muscular dystrophy.
Pediatric research - 1 Jul 1992
Danko I, Chapman V, Wolff J A
Abstract excerpt
The mdx mouse has been used for the development of cellular and gene therapies for Duchenne muscular dystrophy. The relatively frequent occurrence of dystrophin-positive muscle cells called revertants has hampered these efforts by interfering with data interpretation. The mdx4cv and mdx5cv dystrophin mouse mutants have approximately 10-fold fewer revertants than the mdx mutant at both 2 and 6 mo. The mdx3cv...
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