Article
The frequency of revertants in mdx mouse genetic models for Duchenne muscular dystrophy.
Pediatric research - 1 Jul 1992
Danko I, Chapman V, Wolff J A
Abstract excerpt
The mdx mouse has been used for the development of cellular and gene therapies for Duchenne muscular dystrophy. The relatively frequent occurrence of dystrophin-positive muscle cells called revertants has hampered these efforts by interfering with data interpretation. The mdx4cv and mdx5cv dystrophin mouse mutants have approximately 10-fold fewer revertants than the mdx mutant at both 2 and 6 mo. The mdx3cv...
Topics
- Animals
- Dystrophin
- Fluorescent Antibody Technique
- Immunoblotting
- Mice
- Mice, Mutant Strains
- Models, Genetic
- Muscles
- Muscular Dystrophy, Animal
- Mutation
- Myocardium