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Article

Specific removal of the nonsense mutation from the mdx dystrophin mRNA using antisense oligonucleotides.

Neuromuscular disorders : NMD - 1 Jul 1999

Wilton S D, Lloyd F, Carville K, Fletcher S, Honeyman K, Agrawal S, Kole R

Abstract excerpt

The mdx mouse, which carries a nonsense mutation in exon 23 of the dystrophin gene, has been used as an animal model of Duchenne muscular dystrophy to evaluate cell or gene replacement therapies. Despite the mdx mutation, which should preclude the synthesis of a functional dystrophin protein, rare, naturally occurring dystrophin-positive fibres have been observed in mdx muscle tissue. These dystrophin-positive...

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Source

Identifiers

PMID: 10407856
DOI: 10.1016/s0960-8966(99)00010-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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