Article
Dystrophin gene transcripts skipping the mdx mutation.
Muscle & nerve - 1 Jun 1997
Wilton S D, Dye D E, Laing N G
Abstract excerpt
The mdx mouse, an animal model used to study Duchenne muscular dystrophy, has a nonsense mutation in exon 23 of the dystrophin gene which should result in a truncated protein that cannot be correctly localized at the sarcolemma of the muscle fibers. Immunohistochemical staining with antidystrophi...
Topics
- Animals
- Base Sequence
- Disease Models, Animal
- Dystrophin
- Mice
- Mice, Inbred C57BL
- Mice, Inbred mdx
- Molecular Sequence Data
- Mutation
- Transcription, Genetic