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Article

Nuc2p, a subunit of the anaphase-promoting complex, inhibits septation initiation network following cytokinesis in fission yeast.

PLoS genetics - 1 Jan 2008

Chew Ting Gang, Balasubramanian Mohan K

Abstract excerpt

In most cell types, mitosis and cytokinesis are tightly coupled such that cytokinesis occurs only once per cell cycle. The fission yeast Schizosaccharomyces pombe divides using an actomyosin-based contractile ring and is an attractive model for the study of the links between mitosis and cytokinesis. In fission yeast, the anaphase-promoting complex/cyclosome (APC/C) and the septation initiation network (SIN), a...

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Source

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Identifiers

PMID: 18225957
DOI: 10.1371/journal.pgen.0040017
PMCID: PMC2213707

Genes

APC
CHFR
TPR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nuc2p, a subunit of the anaphase-promoting complex, inhibits septation initiation network following cytokinesis in fission yeast.PMID 18225957Read ↗

Rng2p, a protein required for cytokinesis in fission yeast, is a component of the actomyosin ring and the spindle pole body.Semantic proximity Read ↗

The nucleolar Net1/Cfi1-related protein Dnt1 antagonizes the septation initiation network in fission yeast.Semantic proximity Read ↗

Etd1p is a novel protein that links the SIN cascade with cytokinesis.Semantic proximity Read ↗

Septins regulate the equatorial dynamics of the separation initiation network kinase Sid2p and glucan synthases to ensure proper cytokinesis.Semantic proximity Read ↗

Cytokinetic actomyosin ring formation and septation in fission yeast are dependent on the full recruitment of the polo-like kinase Plo1 to the spindle pole body and a functional spindle assembly checkpoint.Semantic proximity Read ↗

S. pombe cdc11p, together with sid4p, provides an anchor for septation initiation network proteins on the spindle pole body.Semantic proximity Read ↗

Identification of functional domains within the septation initiation network kinase, Cdc7.Semantic proximity Read ↗

IQGAP and mitotic exit network (MEN) proteins are required for cytokinesis and re-polarization of the actin cytoskeleton in the budding yeast, Saccharomyces cerevisiae.Semantic proximity Read ↗

Dma1 prevents mitotic exit and cytokinesis by inhibiting the septation initiation network (SIN).Semantic proximity Read ↗

The S. pombe cytokinesis NDR kinase Sid2 activates Fin1 NIMA kinase to control mitotic commitment through Pom1/Wee1.Semantic proximity Read ↗

Timely septation requires SNAD-dependent spindle pole body localization of the septation initiation network components in the filamentous fungus Aspergillus nidulans.Semantic proximity Read ↗

Separate roles of IQGAP Rng2p in forming and constricting the Schizosaccharomyces pombe cytokinetic contractile ring.Semantic proximity Read ↗

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