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Article

TLS (FUS) binds RNA in vivo and engages in nucleo-cytoplasmic shuttling

1 Aug 1997

Abstract excerpt

TLS, the product of a gene commonly translocated in liposarcomas (TLS), is prototypical of a newly identified class of nuclear proteins that contain a C-terminal domain with a distinct RNA recognition motif (RRM) surrounded by Arg-Gly-Gly (RGG) repeats. Its unique N terminus serves as an essential transforming domain for a number of fusion oncoproteins in human sarcomas and leukemias. In this study we use an in...

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Identifiers

PMID: 9264461
DOI: 10.1242/jcs.110.15.1741

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