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Article

Liposarcoma initiated by FUS/TLS-CHOP: the FUS/TLS domain plays a critical role in the pathogenesis of liposarcoma.

Oncogene - 7 Dec 2000

Pérez-Losada J, Sánchez-Martín M, Rodríguez-García M A, Pérez-Mancera P A, Pintado B, Flores T, Battaner E, Sánchez-Garćia I

Abstract excerpt

The most common chromosomal translocation in liposarcomas, t(12;16)(q13;p11), creates the FUS/TLS-CHOP fusion gene. We previously developed a mouse model of liposarcoma by expressing FUS-CHOP in murine mesenchymal stem cells. In order to understand how FUS-CHOP can initiate liposarcoma, we have now generated transgenic mice expressing altered forms of the FUS-CHOP protein. Transgenic mice expressing high levels...

Read the complete abstract on PubMed

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Share to Adipocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heterogeneous-Nuclear Ribonucleoproteins

Share to Liposarcoma

Share to Oncogene Proteins, Fusion

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Share to RNA-Binding Protein FUS

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Source

Identifiers

PMID: 11146553
DOI: 10.1038/sj.onc.1204018

Genes

FUS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Liposarcoma initiated by FUS/TLS-CHOP: the FUS/TLS domain plays a critical role in the pathogenesis of liposarcoma.PMID 11146553Read ↗

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