Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Translocated in liposarcoma regulates the distribution and function of mammalian enabled, a modulator of actin dynamics.

The FEBS journal - 1 Apr 2016

Sugiura Tomohito, Matsuda Shuji, Kurosaka Satoshi, Nakai Nobuhiro, Fukumoto Keita, Takahashi Tetsuya, Maruyama Hirofumi, Imaizumi Kazunori, Matsumoto Masayasu, Takumi Toru

Abstract excerpt

Translocated in liposarcoma/fused in sarcoma (TLS/FUS) is an RNA-binding protein that regulates the splicing pattern of mRNA transcripts and is known to cause a type of familial amyotrophic lateral sclerosis (ALS). In the absence of TLS, Mammalian enabled (Mena), an actin-regulatory protein and a target of TLS, undergoes preferential alternative splicing. In the present study, we show that the ablation of TLS...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actin Cytoskeleton
Share to Cytoskeletal Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryo, Mammalian

Share to Microfilament Proteins

Share to Microscopy, Fluorescence

Share to Real-Time Polymerase Chain Reaction

Share to RNA-Binding Protein FUS

Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Source

Identifiers

PMID: 26896672
DOI: 10.1111/febs.13685

Genes

FUS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Translocated in liposarcoma regulates the distribution and function of mammalian enabled, a modulator of actin dynamics.PMID 26896672Read ↗

ALS-associated mutations in FUS disrupt the axonal distribution and function of SMN.Semantic proximity Read ↗

Functions of FUS/TLS From DNA Repair to Stress Response: Implications for ALSSemantic proximity Read ↗

Autosomal dominant inheritance of rapidly progressive amyotrophic lateral sclerosis due to a truncation mutation in the fused in sarcoma (FUS) gene.Semantic proximity Read ↗

Intracellular localization and splicing regulation of FUS/TLS are variably affected by amyotrophic lateral sclerosis-linked mutations.Semantic proximity Read ↗

Loss of fused in sarcoma (FUS) promotes pathological Tau splicing.Semantic proximity Read ↗

Characterization of FUS mutations in amyotrophic lateral sclerosis using RNA-Seq.Semantic proximity Read ↗

ALS mutations in TLS/FUS disrupt target gene expression.Semantic proximity Read ↗

Nuclear transport impairment of amyotrophic lateral sclerosis‐linked mutations in FUS/TLSSemantic proximity Read ↗

Knockdown of the Drosophila fused in sarcoma (FUS) homologue causes deficient locomotive behavior and shortening of motoneuron terminal branches.Semantic proximity Read ↗

FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations.Semantic proximity Read ↗

Functional characterization of a FUS mutant zebrafish line as a novel genetic model for ALS.Semantic proximity Read ↗

Multiple lines of evidence for disruption of nuclear lamina and nucleoporins in FUS amyotrophic lateral sclerosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.