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Article

[Effect of chlorocresol vs caffeine on muscle contracture in malignant hyperthermia susceptible patients].

Harefuah - 15 Jun 1997

Ben-Abraham R, Krivosic-Horber R M, Haudcoeur G, Perel A, Adnet P J

Abstract excerpt

The phenotype of susceptibility to malignant hyperthermia (MHS); can only be detected reliably by the in vitro caffeine-halothane contracture test (CHCT). Enhanced sensitivity of the calcium-induced calcium release mechanism is responsible for the exaggerated contracture response of skeletal muscle fibers from MHS patients to halothane and caffeine. Chlorocresol was demonstrated to be a potent activator of Ca++...

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Identifiers

PMID: 9264187

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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[Effect of chlorocresol vs caffeine on muscle contracture in malignant hyperthermia susceptible patients].PMID 9264187Read ↗

Phenotyping malignant hyperthermia susceptibility by measuring halothane-induced changes in myoplasmic calcium concentration in cultured human skeletal muscle cells.Semantic proximity Read ↗

Results of contracture tests with halothane, caffeine, and ryanodine depend on different malignant hyperthermia-associated ryanodine receptor gene mutations.Semantic proximity Read ↗

Similar susceptibility to halothane, caffeine and ryanodine in vitro reflects pharmacogenetic variability of malignant hyperthermia.Semantic proximity Read ↗

Increased sensitivity to 4-chloro-m-cresol and caffeine in primary myotubes from malignant hyperthermia susceptible individuals carrying the ryanodine receptor 1 Thr2206Met (C6617T) mutation.Semantic proximity Read ↗

Comparative analysis of in vitro contracture tests with ryanodine and a combination of ryanodine with either halothane or caffeine: a comparative investigation in malignant hyperthermia.Semantic proximity Read ↗

Patients with malignant hyperthermia demonstrate an altered calcium control mechanism in B lymphocytes.Semantic proximity Read ↗

[Modern diagnostic approaches to malignant hyperthermia susceptibility].Semantic proximity Read ↗

Calcium release from sarcoplasmic reticulum is facilitated in human myotubes derived from carriers of the ryanodine receptor type 1 mutations Ile2182Phe and Gly2375Ala.Semantic proximity Read ↗

The differential effect of halothane and 1,2-dichlorohexafluorocyclobutane on in vitro muscle contractures of patients susceptible to malignant hyperthermia.Semantic proximity Read ↗

Statins alter intracellular calcium homeostasis in malignant hyperthermia susceptible individuals.Semantic proximity Read ↗

Sevoflurane is less sensitive than halothane for in vitro detection of malignant hyperthermia susceptibility.Semantic proximity Read ↗

Analysis of human cultured myotubes responses mediated by ryanodine receptor 1.Semantic proximity Read ↗

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