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Article

Patients with malignant hyperthermia demonstrate an altered calcium control mechanism in B lymphocytes.

Anesthesiology - 1 Nov 2002

Sei Yoshitatsu, Brandom Barbara W, Bina Saiid, Hosoi Eiji, Gallagher Kathleen L, Wyre Hadley W, Pudimat Paul A, Holman Steve J, Venzon David J, Daly John W, Muldoon Sheila

Abstract excerpt

BACKGROUND: Altered Ca2+ homeostasis in skeletal muscle is a key molecular event triggering malignant hyperthermia (MH) in malignant hyperthermia-susceptible (MHS) individuals. Genetic studies have shown that mutations in the type 1 ryanodine receptor (RYR1) are associated with MH susceptibility. Because human B lymphocytes express the RYR1, it is hypothesized that Ca2+ homeostasis in B lymphocytes is altered in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12411786
DOI: 10.1097/00000542-200211000-00005

Genes

RYR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Patients with malignant hyperthermia demonstrate an altered calcium control mechanism in B lymphocytes.PMID 12411786Read ↗

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RYR1 mutations linked to malignant hyperthermia susceptibility are associated with phenotypic changes in human B-lymphocytes.Semantic proximity Read ↗

Identification and biochemical characterization of a novel ryanodine receptor gene mutation associated with malignant hyperthermia.Semantic proximity Read ↗

Calcium release from sarcoplasmic reticulum is facilitated in human myotubes derived from carriers of the ryanodine receptor type 1 mutations Ile2182Phe and Gly2375Ala.Semantic proximity Read ↗

Sequence capture and massively parallel sequencing to detect mutations associated with malignant hyperthermia.Semantic proximity Read ↗

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