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Article

Molecular modeling of D151Y and M391T mutations in the LDL receptor.

Biochemical and biophysical research communications - 12 Dec 2008

Jeenduang Nutjaree, Promptmas Chamras, Pongrapeeporn Klai-Upsorn S, Porntadavity Sureerut

Abstract excerpt

The low-density lipoprotein receptor (LDLR) is a key regulator of cholesterol homeostasis, and defects in the function of LDLR result in familial hypercholesterolemia (FH). In the present study, we performed structural analyses of two novel LDLR mutations, D151Y and M391T. Both mutations occurred in conserved residues of LDLR. The D151Y mutation, in the ligand binding domain, caused an elimination of a hydrogen...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18929537
DOI: 10.1016/j.bbrc.2008.09.151

Genes

LDLR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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