Mutations in the N-terminal domain of human immunodeficiency virus type 1 nucleocapsid protein affect virion core structure and proviral DNA synthesis.

doi:10.1128/JVI.71.9.6973-6981.1997

Article

Mutations in the N-terminal domain of human immunodeficiency virus type 1 nucleocapsid protein affect virion core structure and proviral DNA synthesis.

Journal of virology - 1 Sept 1997

Berthoux L, Péchoux C, Ottmann M, Morel G, Darlix J L

Abstract excerpt

Nucleocapsid protein NCp7 of human immunodeficiency virus type 1 (HIV-1) is a small basic nucleic acid binding protein containing two zinc fingers of the form (CX2CX4HX4C) and is present at about 2,000 copies inside the viral core. NCp7 molecules are tightly associated with the genomic RNA dimer...

Topics

Amino Acid Sequence
Animals
Binding Sites
COS Cells
Capsid
Capsid Proteins
DNA, Viral
Gene Products, gag
HIV Core Protein p24
HIV-1
HeLa Cells
Humans
Molecular Sequence Data
Mutation
Proviruses
RNA, Viral
Viral Proteins
Virion

Mutations in the N-terminal domain of human immunodeficiency virus type 1 nucleocapsid protein affect virion core structure and proviral DNA synthesis.

Abstract excerpt

Topics

Discuss the evidence