Article
Intracellular HIV-1 Gag localization is impaired by mutations in the nucleocapsid zinc fingers.
Retrovirology - 3 Aug 2007
Grigorov Boyan, Décimo Didier, Smagulova Fatima, Péchoux Christine, Mougel Marylène, Muriaux Delphine, Darlix Jean-Luc
Abstract excerpt
BACKGROUND: The HIV-1 nucleocapsid protein (NC) is formed of two CCHC zinc fingers flanked by highly basic regions. HIV-1 NC plays key roles in virus structure and replication via its nucleic acid binding and chaperoning properties. In fact, NC controls proviral DNA synthesis by reverse transcrip...
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