Article
Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1.
Journal of virology - 1 Feb 1996
Trkola A, Purtscher M, Muster T, Ballaun C, Buchacher A, Sullivan N, Srinivasan K, Sodroski J, Moore J P, Katinger H
Abstract excerpt
We have isolated and characterized human monoclonal antibody 2G12 to the gp120 surface glycoprotein of human immunodeficiency virus type 1 (HIV-1). This antibody potently and broadly neutralizes primary and T-cell line-adapted clade B strains of HIV-1 in a peripheral blood mononuclear cell-based...
Topics
- Amino Acid Sequence
- Antibodies, Monoclonal
- Antibody-Dependent Cell Cytotoxicity
- Cell Line
- Complement C3
- Epitope Mapping
- Giant Cells
- Glycosylation
- HIV Antibodies
- HIV Envelope Protein gp120
- HIV-1
- Humans
- Molecular Sequence Data
- Mutation