Article
A human antibody to the CD4 binding site of gp120 capable of highly potent but sporadic cross clade neutralization of primary HIV-1.
PloS one - 1 Jan 2013
Gach Johannes S, Quendler Heribert, Tong Tommy, Narayan Kristin M, Du Sean X, Whalen Robert G, Binley James M, Forthal Donald N, Poignard Pascal, Zwick Michael B
Abstract excerpt
Primary isolates of HIV-1 resist neutralization by most antibodies to the CD4 binding site (CD4bs) on gp120 due to occlusion of this site on the trimeric spike. We describe 1F7, a human CD4bs monoclonal antibody that was found to be exceptionally potent against the HIV-1 primary isolate JR-FL. However, 1F7 failed to neutralize a patient-matched primary isolate, JR-CSF even though the two isolates differ by <10%...
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