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Article

Characterization of mutants of human immunodeficiency virus type 1 that have escaped neutralization by a monoclonal antibody to the gp120 V2 loop.

Journal of virology - 1 Feb 1994

Yoshiyama H, Mo H, Moore J P, Ho D D

Abstract excerpt

The biologically cloned human immunodeficiency virus type 1 (HIV-1) RF isolate is sensitive to neutralization by the murine monoclonal antibody (MAb) G3-4 to a conformationally sensitive epitope in the V2 loop of HIV-1 gp120. To assess how variation in the V2 amino acid sequence affects neutralization by this MAb, we cultured RF in the presence of G3-4 to select neutralization escape mutants. Three such mutants...

Topics

Amino Acid Sequence
Animals
Antibodies, Monoclonal
Base Sequence
Cloning, Molecular
Epitopes
HIV Antibodies
HIV Envelope Protein gp120
HIV-1
Mice
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Neutralization Tests

Sequence Analysis, DNA

Sequence Homology, Amino Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 7507188
DOI: 10.1128/JVI.68.2.974-978.1994
PMCID: PMC236535

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7507188-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Characterization of mutants of human immunodeficiency virus type 1 that have escaped neutralization by a monoclonal antibody to the gp120 V2 loop.PMID 7507188Read ↗

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