Article
The C108g epitope in the V2 domain of gp120 functions as a potent neutralization target when introduced into envelope proteins derived from human immunodeficiency virus type 1 primary isolates.
Journal of virology - 1 Jun 2005
Pinter Abraham, Honnen William J, D'Agostino Paul, Gorny Miroslaw K, Zolla-Pazner Susan, Kayman Samuel C
Abstract excerpt
Monoclonal antibodies (MAbs) directed against epitopes in the V2 domain of human immunodeficiency virus type 1 gp120 often possess neutralizing activity, but these generally are highly type specific, neutralize only laboratory isolates, or have low potency. The most potent of these is C108g, directed against a type-specific epitope in HXB2 and BaL gp120s, which is glycan dependent and, in contrast to previous...
Topics
- Amino Acid Sequence
- Animals
- Antibodies, Monoclonal
- Disulfides
- Epitopes
- Gene Products, env
- HIV Antibodies
- HIV Envelope Protein gp120
- HIV-1
- Humans
- In Vitro Techniques
- Molecular Sequence Data
- Mutation