Article
Lack of allelic association of dopamine D4 receptor gene polymorphisms with Parkinson's disease in a Chinese population.
Movement disorders : official journal of the Movement Disorder Society - 1 Mar 1999
Wan D C, Law L K, Ip D T, Cheung W T, Ho W K, Tsim K W, Kay R, Woo J, Pang C P
Abstract excerpt
Parkinson's disease (PD) is a neurodegenerative disease caused by a multitude of environmental, neurochemical, and genetic factors. The gene for human dopamine D4 receptor (DRD4) has been considered as a plausible candidate for the pathogenesis of PD. Different dopamine D4 receptor allelic forms have variable affinity toward certain neuroleptics such as clozapine, suggesting a role for dopamine D4 receptors in...
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