Article
Genetic variations associated with psoriasis and psoriatic arthritis found by genome-wide association.
Dermatologic therapy - 1 Jan 2000
Duffin Kristina Callis, Woodcock Jamie, Krueger Gerald G
Abstract excerpt
Psoriasis and psoriatic arthritis are immune disorders with a complex polygenic basis. HLA-Cw6, which lies in the major histocompatibility region on chromosome 6, is considered the major genetic determinant of psoriasis. Recent genome-wide association studies have identified new variants outside of the MHC with relevance to the immunology of psoriasis. Variants in or near genes that encode subunits of cytokines...
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