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Article

Genomic stability and functional activity may be lost in telomerase-transduced human CD8+ T lymphocytes.

Blood - 15 Oct 2005

Schreurs Marco W J, Hermsen Mario A J A, Geltink Ramon I Klein, Scholten Kirsten B J, Brink Antoinette A T P, Kueter Esther W M, Tijssen Marianne, Meijer Chris J L M, Ylstra Bauke, Meijer Gerrit A, Hooijberg Erik

Abstract excerpt

To obtain the large amount of T cells required for adoptive immunotherapy in a clinical setting, T-cell lifespan extension by human telomerase reverse transcriptase (hTERT) transduction is of particular interest. However, constitutive expression of hTERT is associated with malignant transformation and thus warrants a detailed evaluation of the safety of hTERT-transduced T cells before clinical application. In...

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Share to CD8-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16002425
DOI: 10.1182/blood-2004-09-3742

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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