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Article

Genomic Adaption and Mutational Patterns in a HaCaT Subline Resistant to Alkylating Agents and Ionizing Radiation.

International journal of molecular sciences - 24 Jan 2021

Ullmann Reinhard, Becker Benjamin Valentin, Rothmiller Simone, Schmidt Annette, Thiermann Horst, Kaatsch Hanns Leonhard, Schrock Gerrit, Müller Jessica, Jakobi Julia, Obermair Richard, Port Matthias, Scherthan Harry

Abstract excerpt

Sulfur mustard (SM) is a chemical warfare agent that can damage DNA via alkylation and oxidative stress. Because of its genotoxicity, SM is cancerogenic and the progenitor of many chemotherapeutics. Previously, we developed an SM-resistant cell line via chronic exposure of the popular keratinocyte cell line HaCaT to increasing doses of SM over a period of 40 months. In this study, we compared the genomic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 33498964
DOI: 10.3390/ijms22031146
PMCID: PMC7865644

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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