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High‐resolution analysis of genetic stability of human adipose tissue stem cells cultured to senescence

23 Oct 2007

Abstract excerpt

The potential use of human mesenchymal stem cells for therapeutic applications implies large scale in vitro culture, increasing the probability of genetic instability and transformation. We examine here the incidence of unbalanced and balanced chromosome rearrangements in polyclonal and single cell-derived cultures of human adipose stem cells to senescence. G-banding karyotyping of the polyclonal cultures shows a...

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PMID: 18419597
DOI: 10.1111/j.1582-4934.2007.00146.x

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