Article
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase.
Proceedings of the National Academy of Sciences of the United States of America - 19 Aug 1997
Myers M P, Stolarov J P, Eng C, Li J, Wang S I, Wigler M H, Parsons R, Tonks N K
Abstract excerpt
Protein tyrosine phosphatases (PTPs) have long been thought to play a role in tumor suppression due to their ability to antagonize the growth promoting protein tyrosine kinases. Recently, a candidate tumor suppressor from 10q23, termed P-TEN, was isolated, and sequence homology was demonstrated with members of the PTP family, as well as the cytoskeletal protein tensin. Here we show that recombinant P-TEN...
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