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Article

An effective method for the in situ synthesis of DNA-CPG conjugates using chemical ligation technology as tools for SNP analysis.

Bioorganic & medicinal chemistry letters - 1 Nov 2007

Ohkubo Akihiro, Tanaka Kunihiko, Taguchi Haruhiko, Seio Kohji, Nagasawa Hiroshi, Tsukahara Toshifumi, Sekine Mitsuo

Abstract excerpt

In this paper, we report a new method for the SNP analysis by using a chemical ligation (CL) technique on CPG plates with high coupling efficiency. This method showed markedly high match/mismatch discrimination ability. Particularly, replacement of thymidine with 2-thiothymidine in DNA probes used in the CL technology resulted in significant improvement of the base discrimination ability of the thymine base in...

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PMID: 17845851
DOI: 10.1016/j.bmcl.2007.07.066

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