Article
Synthesis of oligonucleotides bearing an arylamine modification in the C8-position of 2'-deoxyguanosine.
Nucleosides, nucleotides & nucleic acids - 1 Jan 2005
Meier C, Gräsl S, Detmer I, Marx A
Abstract excerpt
C8-Arylamine-dG adducts were converted into their corresponding 5-O-DMTr-3'-O-phosphoramidite-C8-arylamine-dG derivatives. These compounds were used for the automated synthesis of site-specifically modified oligonucleotides. The oligonucleotides were studied for their CD properties, Tm values, and their effects on primer extension assays using human DNA-polymerase beta.
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