Article
Reprogramming the purine nucleotide cofactor requirement of Drosophila P element transposase in vivo.
The EMBO journal - 16 Jul 1997
Mul Y M, Rio D C
Abstract excerpt
Guanosine triphosphate (GTP)-binding proteins are involved in controlling a wide range of fundamental cellular processes. In vitro studies have indicated a role for GTP during Drosophila P element transposition. Here we show that P element transposase contains a non-canonical GTP-binding domain that is critical for its ability to mediate transposition in Drosophila cells. Moreover, a single amino acid...
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