Xanthine nucleotide-specific G-protein alpha-subunits: a novel approach for the analysis of G-protein-mediated signal transduction.

Abstract excerpt

Pro- and eukaryotic cells express multiple GTP-binding proteins that play crucial roles in signal transduction. GTP-binding proteins possess a highly conserved NKX D motif critically involved in guanine binding. In order to selectively activate a defined GTP-binding protein, base-specificity can be switched from guanine to xanthine by mutating the conserved aspartate into asparagine (D/N-mutation). This approach...

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