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Complete sequence-based screening of TPMT variants in the Korean population.

Pharmacogenetics and genomics - 1 Mar 2015

Kim Hyun-Young, Lee Soo Hyun, Lee Mi-Na, Kim Jong-Won, Kim Young-Ho, Kim Mi Jin, Lee Yoo Min, Kang Ben, Choe Yon Ho, Lee Na Hee, Kim Dong Hwan, Yoo Keon Hee, Sung Ki Woong, Lee Soo-Youn, Koo Hong Hoe

Abstract excerpt

Thiopurine S-methyltransferase (TPMT) is a cytoplasmic enzyme involved in the metabolism of thiopurine drugs and its activity is largely influenced by polymorphisms of the TPMT gene. To date, more than 35 TPMT variants are known to be associated with reduced enzyme activity, but most studies on the TPMT genotype have included only common nonfunctional variants, such as TPMT*2 and TPMT*3. In this study, we carried...

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Identifiers

PMID: 25564374
DOI: 10.1097/FPC.0000000000000117

Genes

TPMT

Variants

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