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Article

Thiopurine S-methyltransferase pharmacogenetics: variant allele functional and comparative genomics.

Pharmacogenetics and genomics - 1 Nov 2005

Salavaggione Oreste E, Wang Liewei, Wiepert Mathieu, Yee Vivien C, Weinshilboum Richard M

Abstract excerpt

Thiopurine S-methyltransferase (TPMT) catalyses the S-methylation of thiopurine drugs. Genetic polymorphisms for TPMT are a major factor responsible for large individual variations in thiopurine toxicity and therapeutic effect. The present study investigated the functional effects of human TPMT v...

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Source

Identifiers

PMID: 16220112
DOI: 10.1097/01.fpc.0000174788.69991.6b

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16220112-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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