Article
Phenotypic features of selective T cell deficiency characterized by absence of CD8+ T lymphocytes and undetectable mRNA for ZAP-70 kinase.
Clinical immunology and immunopathology - 1 Aug 1997
Mazer B, Harbeck R J, Franklin R, Schwinzer R, Kubo R, Hayward A, Gelfand E W
Abstract excerpt
Selective T cell deficiency is a rare immune deficiency characterized by the absence of CD8+ T lymphocytes and depressed/absent T cell function. This syndrome has been associated with mutations in the gene for ZAP-70, a tyrosine kinase that has profound effects on signaling via the T cell receptor. In this paper we describe a patient with selective T cell deficiency and certain phenotypic features that are unique...
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