Article
ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency.
Science (New York, N.Y.) - 10 Jun 1994
Chan A C, Kadlecek T A, Elder M E, Filipovich A H, Kuo W L, Iwashima M, Parslow T G, Weiss A
Abstract excerpt
Protein tyrosine kinases (PTKs) play an integral role in T cell activation and differentiation. Defects in the Src-family PTKs in mice and in T cell lines have resulted in variable defects in thymic development and in T cell antigen receptor (TCR) signal transduction. Here, three siblings are described with an autosomal recessive form of severe combined immunodeficiency disease (SCID) in which ZAP-70, a non-Src...
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