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Article

Defective T cell receptor signaling and CD8+ thymic selection in humans lacking Zap-70 kinase

1 Mar 1994

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Identifiers

PMID: 8124727
DOI: 10.1016/0092-8674(94)90368-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Defective T cell receptor signaling and CD8+ thymic selection in humans lacking Zap-70 kinasePMID 8124727Read ↗

A boy with a novel homozygous ZAP70 mutation presenting with a dermatological phenotype and postnatal decrease in CD8+ T cells.Semantic proximity Read ↗

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ZAP-70 in Signaling, Biology, and DiseaseSemantic proximity Read ↗

Distinct T Cell Developmental Consequences in Humans and Mice Expressing Identical Mutations in the DLAARN Motif of ZAP-70Semantic proximity Read ↗

Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in miceSemantic proximity Read ↗

The immunopathological landscape of human pre-TCRα deficiency: From rare to common variants.Semantic proximity Read ↗

A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70.Semantic proximity Read ↗

Lymphocyte disturbance and functional assessment of the [Asp521Asn] ZAP70 mutation.Semantic proximity Read ↗

A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity.Semantic proximity Read ↗

A novel hypomorphic ζ-chain-associated protein tyrosine kinase 70 kDa mutation with normal CD8+ T cells count.Semantic proximity Read ↗

Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase.Semantic proximity Read ↗

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