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Article

Phenotypical and functional characterization of double-negative (CD4-CD8-) alpha beta T-cell receptor positive cells from an immunodeficient patient.

Scandinavian journal of immunology - 1 Nov 1991

Illum N, Ralfkiaer E, Pallesen G, Geisler C

Abstract excerpt

We have characterized CD4-CD8- double-negative (DN) alpha beta TCR+ T cells from a patient with immunodeficiency, lymphocytosis, lymphadenopathy, and hepatosplenomegaly. The majority of peripheral blood lymphocytes were DN alpha beta TCR+ T cells as evaluated by FACS and biochemical analysis. The DN T cells showed the following phenotype: alpha beta TCR+, gamma delta TCR-, CD2+, CD3+, CD4-, CD5+, CD7-, CD8-,...

Topics

Antigens, CD
CD4 Antigens
CD8 Antigens
Child
Female
Flow Cytometry
Humans
Immunologic Deficiency Syndromes
Lymph Nodes
Lymphocyte Activation
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Antigen, T-Cell, alpha-beta

T-Lymphocytes

Thymus Gland

Source

Identifiers

PMID: 1835126
DOI: 10.1111/j.1365-3083.1991.tb01587.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1835126-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Phenotypical and functional characterization of double-negative (CD4-CD8-) alpha beta T-cell receptor positive cells from an immunodeficient patient.PMID 1835126Read ↗

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