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Article

A mutation in zap-70 protein tyrosine kinase results in a selective immunodeficiency.

Journal of clinical immunology - 1 Nov 1995

Roifman C M

Abstract excerpt

We have previously described a new type of selective T-cell deficiency characterized by persistent infections reminiscent of severe combined immunodeficiency. We show here that selective T-cell deficiency patients carry a mutation of zap-70 protein tyrosine kinase, resulting in a loss of the activity of this kinase. The thymus of zap-70(-1-1) patients shows the presence of CD4CD8 double-positive cells in the...

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Identifiers

PMID: 8613493
DOI: 10.1007/BF01540894

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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