Article
Absolute linkage of celiac disease and dermatitis herpetiformis to HLA-DQ.
Tissue antigens - 1 Jul 1997
Balas A, Vicario J L, Zambrano A, Acuña D, García-Novo D
Abstract excerpt
This report shows the absolute genetic linkage of celiac disease (CD) to the HLA-DQ region, and supports the fact that dermatitis herpetiformis (DH) follows the same pattern of HLA-mediated susceptibility in extensive series of Caucasian Spanish patients. Ninety-five percent of CD (201 of 212) and 100% of DH (55) patients could produce DQ alpha 1*0501-DQ beta 1*02 heterodimers. Negative CD patients for this...
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