Article
Genetic differences in HLA-DQA1* and DQB1* allelic distributions between celiac and control children in Santiago, Chile.
Human immunology - 1 Mar 1999
Pérez-Bravo F, Araya M, Mondragón A, Ríos G, Alarcón T, Roessler J L, Santos J L
Abstract excerpt
Celiac disease is a permanent gluten intolerance strongly associated with HLA class II antigens. The over presentation of particular HLA alleles and haplotypes has been described in several populations. Different lines of evidence obtained during the last years suggest that a particular HLA-DQ heterodimer, encoded by the DQA1*0501 and DQB1*0201 genes in cis or trans conformation, confers the primary disease...
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