Article
Immunoglobulin and HLA-DP genes contribute to the susceptibility to juvenile dermatitis herpetiformis.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics - 1 Jun 1992
Mazzola G, Berrino M, Bersanti M, D'Alfonso S, Cappello N, Bottaro A, Curtoni E S, Fusco P, Vallati M, Bundino S
Abstract excerpt
HLA-DQ genes and gluten diet are the main factors involved in the pathogenesis of Dermatitis Herpetiformis (DH), as well as Coeliac Disease (CD). However other genetic factors are probably relevant, since about 10% of the patients with DH and CD lack the DQA1*0501/B1*0201 heterodimer while the ma...
Topics
- Adolescent
- Alleles
- Base Sequence
- Celiac Disease
- Child
- Child, Preschool
- DNA
- Dermatitis Herpetiformis
- Female
- Gene Frequency
- Genes, Immunoglobulin
- Glutens
- HLA-DP Antigens
- Humans
- Immunoglobulin Switch Region